Immediate early gene activity‐regulated cytoskeletal‐associated protein regulates estradiol‐induced lordosis behavior in female rats

  title={Immediate early gene activity‐regulated cytoskeletal‐associated protein regulates estradiol‐induced lordosis behavior in female rats},
  author={Amy Christensen and Phoebe Dewing and P E Micevych},
  journal={Journal of Neuroscience Research},
Sensory feedback is an important component of any behavior, with each instance influencing subsequent activity. Female sexual receptivity is mediated both by the steroid hormone milieu and interaction with the male. We tested the influence of repeated mating on the level of sexual receptivity in ovariectomized rats treated with estradiol benzoate (EB) once every fourth day to mimic the normal phasic changes of circulating estradiol. Females were divided into two groups: naïve, which were tested… Expand
Copulation induces expression of the immediate early gene Arc in mating-relevant brain regions of the male rat
Surprisingly, prior sexual experience did not impact levels of Arc, suggesting that copulation-induced Arc occurs in both sexually naïve and experienced males. Expand
Sex differences after chronic stress in the expression of opioid-, stress- and neuroplasticity-related genes in the rat hippocampus
Opioid peptides and their receptors re-organize within hippocampal neurons of female, but not male, rats following chronic immobilization stress (CIS) in a manner that promotes drug-related learning.Expand
Sex Differences in Neuroplasticity- and Stress-Related Gene Expression and Protein Levels in the Rat Hippocampus Following Oxycodone Conditioned Place Preference
These sex-specific changes in plasticity, stress and kinase markers in hippocampal circuitry parallel previously observed sex differences in the opioid system after oxycodone CPP. Expand
c-Fos, ΔFosB, BDNF, trkB and Arc Expression in the Limbic System of Male Roman High- and Low-Avoidance Rats that Show Differences in Sexual Behavior: Effect of Sexual Activity
It is confirmed that sexual activity induces neural activation in limbic brain areas involved in motivation and reward, leading to changes in synaptic plasticity with sexual experience acquisition, and show that these depend on the animals' genotypic/phenotypic characteristics. Expand
The Impact of Oxytocin Gene Knockout on Sexual Behavior and Gene Expression Related to Neuroendocrine Systems in the Brain of Female Mice
It is demonstrated that the absence of OT leads to significant changes in the expression of the studied genes (OTR, ERα, ERβ, V1aR), and these changes may contribute to the decreased sexual behavior observed in OTKO females. Expand
Plasma membrane G protein-coupled estrogen receptor 1 (GPER) mediates rapid estradiol facilitation of sexual receptivity through the orphanin-FQ-ORL-1 system in estradiol primed female rats
Data indicate that membrane GPER mediates the E2/E-Biotin facilitation of lordosis by inducing OFQ/N neurotransmission, which inhibits β-END neurotransmission to reduce MPN MOP activation. Expand
Neuroanatomical dichotomy of sexual behaviors in rodents: a special emphasis on brain serotonin
This review aims to examine the basics of the components of female and male sexual behavior and the participation of the serotonin system in the modulation of these behaviors, with emphasis on rodents. Expand
Extranuclear signaling by ovarian steroids in the regulation of sexual receptivity
This year marks the 50th anniversary of the publications describing a uterine estrogen-specific binding protein, an estrogen receptor (ER) and a rapid expansion of understanding of the anatomical locations of ERs and PGRs throughout the brain. Expand
Anatomical Markers of Activity in Hypothalamic Neurons.
  • G. Hoffman
  • Medicine, Biology
  • Comprehensive Physiology
  • 2020
Potential markers will be presented and, where possible, placed into perspective in terms of when and how these methods pertain to hypothalamic function, and discussion of methodological limitations and the power of combining approaches to understand neuronal function is included. Expand


Sexual Behaviour Induces the Expression of Activity‐Regulated Cytoskeletal Protein and Modifies Neuronal Morphology in the Female Rat Ventromedial Hypothalamus
These studies suggest that mating behaviour produces short‐term changes in structural proteins and long‐term, selective changes in dendrite morphology, which then may influence future behaviours and/or physiology. Expand
Membrane-Initiated Estradiol Signaling Regulating Sexual Receptivity
Evidence for and against their participation in sexual receptivity by acting in the lordosis-regulating circuit are presented, suggesting a common mechanism through which mERs are coupled to intracellular signaling cascades, not just in regulating reproduction, but in actions throughout the neuraxis including the cortex, hippocampus, striatum, and dorsal root ganglias. Expand
Expression and regulation of the immediate-early gene product Arc in the accessory olfactory bulb after mating in male rat
It is suggested that Arc, an activity-regulated cytoskeleton-associated protein, plays an important role in neuronal plasticity in the accessory olfactory bulb. Expand
Fos Expression in the Rat Brain Following Vaginal‐Cervical Stimulation by Mating and Manual Probing
Previous electrophysiological and [14C]2‐deoxy‐D‐glucose studies collectively show that neurons in the medial preoptic area, ventromedial hypothalamus and midbrain central gray respond to manual VCS, while immunocytochemically labeled brain sections for Fos are used to detect VCS‐responsive neurons in hormone‐primed animals receiving VCS by mating or manual probing. Expand
Temporal and Concentration‐Dependent Effects of Oestradiol on Neural Pathways Mediating Sexual Receptivity
It is demonstrated that underlying this inhibition is oestradiol acting in the arcuate nucleus to induce β‐endorphin release, which inhibits the medial preoptic nucleus through a μ‐opioid receptor mechanism. Expand
Patterns of induction of the immediate-early genes c-fos and egr-1 in the female rat brain following differential amounts of mating stimulation.
It is demonstrated that mating is differentially effective in inducing FOS expression in responsive brain areas and point to the medial amygdala as a site in which summation of intromissive stimulation may occur. Expand
Mating behavior induces differential Arc expression in the main and accessory olfactory bulbs of adult rats
Results showed that Arc-immunoreactivity was enhanced when the AOB received both afferent and efferent information during mating behavior, which directly associates the pheromonal information with mating behavior. Expand
The Synaptic Organization of VMH Neurons That Mediate the Effects of Estrogen on Sexual Behavior
These results represent initial steps toward unraveling the local circuit that mediates estrogenic action on a specific reproductive behavior and suggest that estrogen can increase spine density indirectly indirectly. Expand
Gonadal steroid control of preprocholecystokinin mRNA expression in the limbic‐hypothalamic circuit: Comparison of adult with neonatal steroid treatments
The data suggest that, during neonatal development, estrogen determines the constitutive expression of pCCK mRNA in the medial amygdala and bed nucleus of the stria terminalis, resulting in higher levels of p CCK mRNA expression in males than in females. Expand
Estrogen stimulates activity-regulated cytoskeleton associated protein (Arc) expression via the MAPK- and PI-3K-dependent pathways in SH-SY5Y cells
It is found that estrogen markedly increased Arc mRNA and protein expression in SH-SY5Y cells, demonstrating the possible mechanisms of estrogen-induced synaptic plasticity, as well as memory consolidation. Expand