Immediate early gene X-1 interacts with proteins that modulate apoptosis.

  title={Immediate early gene X-1 interacts with proteins that modulate apoptosis.},
  author={Rajiv Kumar and Ward H Lutz and Elena M Frank and Hee-Jeong Im},
  journal={Biochemical and biophysical research communications},
  volume={323 4},
Immediate early gene X-1 (IEX-1) modulates apoptosis, cellular growth, mechanical strain-induced cardiac hypertrophy, and vascular intimal hyperplasia. To determine how IEX-1 alters apoptosis, we performed yeast two-hybrid studies using IEX-1 as the "bait" protein, and examined interactions between IEX-1 and proteins expressed by a human kidney cDNA expression library. We found that IEX-1 interacts with several proteins of which at least four are known to play a role in the regulation of… CONTINUE READING

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