Immediate and delayed hippocampal neuronal loss induced by kainic acid during early postnatal development in the rat.

@article{Humphrey2002ImmediateAD,
  title={Immediate and delayed hippocampal neuronal loss induced by kainic acid during early postnatal development in the rat.},
  author={William M Humphrey and Hongxin Dong and Cynthia A. Csernansky and John G. Csernansky},
  journal={Brain research. Developmental brain research},
  year={2002},
  volume={137 1},
  pages={1-12}
}
The degree to which the neonatal hippocampus is resistant to the effects of excitotoxins, such as kainic acid (KA) remains uncertain. Previously, we showed delayed loss of hippocampal neurons during pubescence in neonatal rats subjected to intracerebroventricular (i.c.v.) KA administration (10 nmol) at postnatal day 7 (P7). To further characterize the time course as well as the underlying mechanisms of this neuronal loss, we administered i.c.v. KA (10 or 50 nmol) to P7 preweanling rats. Brain… CONTINUE READING
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