Immediate Early and Early Lytic Cycle Proteins Are Frequent Targets of the Epstein-Barr Virus–induced Cytotoxic T Cell Response

@article{Steven1997ImmediateEA,
  title={Immediate Early and Early Lytic Cycle Proteins Are Frequent Targets of the Epstein-Barr Virus–induced Cytotoxic T Cell Response},
  author={N. Steven and N Annels and Anil Kumar and A. M. Leese and M G Kurilla and A Rickinson},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={185},
  pages={1605 - 1618}
}
Epstein-Barr virus (EBV), a human gamma-herpesvirus, can establish both nonproductive (latent) and productive (lytic) infections. Although the CD8+ cytotoxic T lymphocyte (CTL) response to latently infected cells is well characterized, very little is known about T cell controls over lytic infection; this imbalance in our understanding belies the importance of virus-replicative lesions in several aspects of EBV disease pathogenesis. The present work shows that the primary CD8+ CTL response to… CONTINUE READING
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Epstein-Barr virus

  • A. B. Rickinson, E. Kieff
  • editors. Lippincott-Raven Publishers…
  • 1996
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