Immediate‐type hypersensitivity to polyethylene glycols: a review

@article{Wenande2016ImmediatetypeHT,
  title={Immediate‐type hypersensitivity to polyethylene glycols: a review},
  author={Emily Wenande and Lene Heise Garvey},
  journal={Clinical \& Experimental Allergy},
  year={2016},
  volume={46},
  pages={907 - 922}
}
Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. Although generally considered biologically inert, cases of mild to life‐threatening immediate‐type PEG hypersensitivity are reported with increasing frequency. Nevertheless, awareness of PEG's allergenic potential remains low, due to a general lack of suspicion towards excipients and insufficient product labelling. Information on immediate‐type reactions to PEG is limited to anecdotal… 
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A review of the evidence-based literature outlining epidemiology and mechanisms of excipient reactions and strategies for heightened recognition and allergy testing is provided.
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All dental healthcare practitioners should be aware of a potentially life-threatening allergy to PEG, an excipient often overlooked during investigation of anaphylaxis.
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