Immature reticulocyte fraction (IRF) monitored in elite athletes during a whole season.

  title={Immature reticulocyte fraction (IRF) monitored in elite athletes during a whole season.},
  author={Giuseppe Banfi and Alberto Dolci and Marco Freschi and Chiara Verdini},
  journal={Clinical and laboratory haematology},
  volume={27 3},
Sir, in a previous report (Banfi et al., 2004), we described the peculiar behaviour of the parameter immature reticulocyte fraction (IRF) in elite athletes. This parameter showed higher values in athletes than those in sedentary people, although the reference ranges are also applicable to them. The bone marrow of athletes is continuously stimulated because of the accelerated iron metabolism. The evaluation of reticulocyte counts and related parameters are crucial to monitor iron metabolism in… 
Behaviour of reticulocyte counts and immature reticulocyte fraction during a competitive season in élite athletes of four different sports
The validity of the use of Ret counts for antidoping purposes and also for evaluating health status and iron metabolism of sportsmen are confirmed.
The utility of immature reticulocyte fraction as an indicator of erythropoietic response to altitude training in elite cyclists
The results indicate that IRF is a sensitive marker of erythropoietic status in athletes undergoing altitude training and subsequent loss of EPO stimuli on return to sea level.
Reticulocyte count, mean reticulocyte volume, immature reticulocyte fraction, and mean sphered cell volume in elite athletes: reference values and comparison with the general population
No statistical differences were observed among different sports, whereas differences were remarked in football and rugby players between the samples Drawn before the start of competitive season and the samples drawn during the season, demonstrating that reticulocyte counts and parameters are useful for monitoring sportsmen.
Reticulocyte profile in top-level alpine skiers during four consecutive competitive seasons
The validity of the use of Ret counts for anti-doping purposes is confirmed and inter-individual variability is quite high, thus, Ret and [Hb] modifications should be referred only to the single athlete.
Seasonal variations of haematological parameters in athletes
It is summarized that some haematological parameters can be influenced by long-term training and competition periods and the modifications are more evident in cycling, running, swimming than they are in football and rugby.
Reticulocytes in Sports Medicine
The importance of reticulocytes in sports medicine derives from their sensitivity, the highest among haematology parameters, in identifying the bone marrow stimulation, especially when recombinant human erythropoietin is fraudulently used.
Reticulocyte and haemoglobin profiles in elite triathletes over four consecutive seasons
The Blood Passport looks for uncommon changes overtime in reticulocytes percentage, as a variable of the OFF‐hr score, and haemoglobin concentration reflecting potential doping violations, but few studies have actually investigated the concurrent stability of Ret % and Hb in athletes over extended periods of time.
Indicators of iron status in elite soccer players during the sports season
The variability of the iron status indicators in elite soccer players seems to be stable and poorly related to training phase during sports season.
Haematological parameters in elite rugby players during a competitive season.
Haematological and iron metabolism parameters in the elite rugby players examined during a whole season fall within physiological range of values, and the variability of the parameters during the season is related to training and competition workload.
Decreased mean sphered cell volume values in top-level rugby players are related to the intravascular hemolysis induced by exercise.
The MSCV decrease in association with an indirect bilirubin increase is a specific sign of erythrocyte destruction, and specific training and competitions schemes and diet or therapy modifications should be decided according to their values.


Preanalytical phase of sport biochemistry and haematology.
  • G. Banfi, A. Dolci
  • Biology
    The Journal of sports medicine and physical fitness
  • 2003
A practical review of preanalytical aspects of principal analyses applied to the athletes, which includes the choice of anticoagulant and its limits for haematological tests, the preparation and manipulation of specimens for hormonological investigation, especially for labile molecules, and for cardiac markers, lactate, cytokines, micronutrients, antioxidant molecules.
Evaluation of the Abbott Cell Dyn 4000 automated fluorescent reticulocyte measurements: comparison with manual, FACScan and Sysmex R1000 methods.
A high performance level for the CD4000 automated fluorescent reticulocyte method is confirmed after the first evaluation of this method which was undertaken by three independent reference laboratories in Belgium, Germany and Italy.