Immature myeloid cells induced by a high-fat diet contribute to liver inflammation.

@article{Deng2009ImmatureMC,
  title={Immature myeloid cells induced by a high-fat diet contribute to liver inflammation.},
  author={Zhong-bin Deng and Yuelong Liu and Cunren Liu and Xiaoyu Xiang and Jianhua Wang and Ziqiang Cheng and Spandan V. Shah and Shuangyin Zhang and Liming Zhang and Xiaoying Zhuang and Sue Michalek and William E. Grizzle and Huang-ge Zhang},
  journal={Hepatology},
  year={2009},
  volume={50 5},
  pages={1412-20}
}
UNLABELLED Chronic inflammation plays a critical role in promoting obesity-related disorders, such as fatty liver disease. The inflammatory cells that mediate these effects remain unknown. This study investigated the accumulation of immature myeloid cells in the liver and their role in liver inflammation. We found that the accumulation of immature myeloid cells, i.e., CD11b(+)Ly6C(hi)Ly6G(-) cells, in the liver of B6 mice fed a high-fat diet contribute to liver inflammation. Adoptive transfer… CONTINUE READING
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