Immature human dendritic cells express asialoglycoprotein receptor isoforms for efficient receptor-mediated endocytosis.

@article{Valladeau2001ImmatureHD,
  title={Immature human dendritic cells express asialoglycoprotein receptor isoforms for efficient receptor-mediated endocytosis.},
  author={Jenny Valladeau and Val{\'e}rie Duvert-Frances and Jing Pin and Monique J. Kleijmeer and Smina Ait-Yahia and Odile Ravel and Christlein Vincent and F{\'e}lix Vega and Alison Helms and Dan Gorman and Sandra Zurawski and Gerard Zurawski and Jill W. Ford and Sem Saeland},
  journal={Journal of immunology},
  year={2001},
  volume={167 10},
  pages={
          5767-74
        }
}
In a search for genes expressed by dendritic cells (DC), we have cloned cDNAs encoding different forms of an asialoglycoprotein receptor (ASGPR). The DC-ASGPR represents long and short isoforms of human macrophage lectin, a Ca(2+)-dependent type II transmembrane lectin displaying considerable homology with the H1 and H2 subunits of the hepatic ASGPR. Immunoprecipitation from DC using an anti-DC-ASGPR mAb yielded a major 40-kDa protein with an isoelectric point of 8.2. DC-ASGPR mRNA was observed… CONTINUE READING

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