Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.

@article{Dluzniewska2007ImmatureHC,
  title={Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.},
  author={Joanna Dluzniewska and Liangxing Zou and Ian Harmon and Marc T Ellingson and Erik J. Peterson},
  journal={European journal of immunology},
  year={2007},
  volume={37 11},
  pages={3208-19}
}
Adhesion- and degranulation-promoting adaptor protein (ADAP) modulates T cell development and function and promotes TCR signaling. Regulation of ADAP protein expression during thymopoiesis and in development of other hematopoietic lineages has not been explored. Using intracellular staining, we detected ADAP protein in bone marrow lymphocyte precursors. Like its binding partner SH2-containing leukocyte phosphoprotein of 76 kDa, ADAP is dynamically regulated during thymocyte positive selection… CONTINUE READING
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