Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively

Abstract

BACKGROUND The human prostacyclin receptor (hIP) undergoes agonist-induced phosphorylation, desensitisation and internalisation and may be recycled to the plasma membrane or targeted for degradation by, as yet, unknown mechanism(s). RESULTS Herein it was sought to investigate the turnover of the hIP under basal conditions and in response to cicaprost… (More)
DOI: 10.1186/1750-2187-4-7

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