Immature CD4+CD8+ thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation.

@article{Cunningham2006ImmatureCT,
  title={Immature CD4+CD8+ thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation.},
  author={Nicole R. Cunningham and Stephen C. Artim and Christen M. Fornadel and Maclean C Sellars and Samuel G. Edmonson and Grant J. Scott and Frank P. Albino and Akriti Mathur and Jennifer A Punt},
  journal={Journal of immunology},
  year={2006},
  volume={177 10},
  pages={6660-6}
}
The orphan steroid receptor, Nur77, is thought to be a central participant in events leading to TCR-mediated clonal deletion of immature thymocytes. Interestingly, although both immature and mature murine T cell populations rapidly up-regulate Nur77 after TCR stimulation, immature CD4+CD8+ thymocytes respond by undergoing apoptosis, whereas their mature… CONTINUE READING