Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

  title={Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination},
  author={Duane R Wesemann and Jennifer M. Magee and Cristian Boboila and Dinis Pedro Calado and Michael P Gallagher and Andrew J. Portuguese and John P Manis and Xiaolong Zhou and Mike Recher and K. Rajewsky and Luigi D Notarangelo and Frederick W Alt},
  booktitle={The Journal of experimental medicine},
Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially expressed Cμ (IgM) constant regions (C(H)) exons with downstream C(H) exons. Stimulation of B cells with anti-CD40 plus interleukin-4 induces CSR from Cμ to Cγ1 (IgG1) and Cε (IgE), the latter of which contributes to the pathogenesis of atopic diseases. Although Cε CSR can occur directly from Cμ, most mature peripheral B cells undergo CSR to Cε indirectly, namely from Cμ to Cγ1, and subsequently to C… CONTINUE READING
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