Imiquimod-induced clearance of HPV is associated with normalization of immune cell counts in usual type vulvar intraepithelial neoplasia.

@article{Terlou2010ImiquimodinducedCO,
  title={Imiquimod-induced clearance of HPV is associated with normalization of immune cell counts in usual type vulvar intraepithelial neoplasia.},
  author={Annelinde Terlou and Manon van Seters and Alex Kleinjan and Claudia Heijmans-Antonissen and Lindy A M Santegoets and Ilse Beckmann and Marc van Beurden and Theo J. M. Helmerhorst and Leen J. Blok},
  journal={International journal of cancer},
  year={2010},
  volume={127 12},
  pages={
          2831-40
        }
}
Recently, we reported on the efficacy of imiquimod for treatment of usual type vulvar intraepithelial neoplasia (uVIN). A histologic regression of uVIN to normal tissue was observed in 58% of patients. As success of treatment is related to clearance of high-risk human papilloma virus (HPV), the aim of our study was to assess differences in immune cell counts and in the expression of p16(INK4a) in VIN tissue before and after imiquimod treatment, in relation to HPV clearance and clinical response… CONTINUE READING

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