Imipramine treatment of opiate-dependent patients with depressive disorders. A placebo-controlled trial.

@article{Nunes1998ImipramineTO,
  title={Imipramine treatment of opiate-dependent patients with depressive disorders. A placebo-controlled trial.},
  author={Edward V. Nunes and Frederic M. Quitkin and Stephen J Donovan and Deborah A Deliyannides and Katja Ocepek-Welikson and Thomas Koenig and Roscoe Brady and Patrick J. McGrath and George W Woody},
  journal={Archives of general psychiatry},
  year={1998},
  volume={55 2},
  pages={153-60}
}
BACKGROUND The literature is inconclusive on the role of antidepressant medications in treating drug dependence. Studies have either not focused on depressed patients or have selected patients with depressive disorders based on cross-sectional symptoms rather than a syndromal diagnosis. A clinical trial of an antidepressant was, therefore, conducted on drug-dependent patients with syndromal depression. METHODS Patients receiving methadone hydrochloride maintenance treatment were selected if… CONTINUE READING

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