Imipramine treatment in diabetic neuropathy: relief of subjective symptoms without changes in peripheral and autonomic nerve function

@article{Sindrup1989ImipramineTI,
  title={Imipramine treatment in diabetic neuropathy: relief of subjective symptoms without changes in peripheral and autonomic nerve function},
  author={S.\oren H. Sindrup and Bent Ejlertsen and Anders Fr\oland and E. H. Sindrup and Kim Br\osen and Lars Freng Gram},
  journal={European Journal of Clinical Pharmacology},
  year={1989},
  volume={37},
  pages={151-153}
}
The effect of imipramine on symptomatic peripheral diabetic neuropathy in 9 patients was examined in a double-blind cross-over study against placebo. The dose of imipramine was adjusted to yield optimal plasma levels of imipramine plus desipramine of 300–750 nM. Imipramine had a clear benificial effect on the symptoms of the neuropathy, whereas no changes in a range of neurophysiological measurements was detected. Despite some adverse effects, especially of an anticholinergic nature, the… CONTINUE READING

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