Imipramine stimulates phospholipase C activity in rat brain.

  title={Imipramine stimulates phospholipase C activity in rat brain.},
  author={Hitoshi Fukuda and Akira Nishida and Hideya Saito and Masanao Shimizu and Sbigeto Yamawaki},
  journal={Neurochemistry international},
  volume={25 6},
We previously demonstrated that antidepressant drugs (ADs) cause Ca2+ release from inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in cultured neurons of rat frontal cortex. The present study examines the mechanism by which tricyclic ADs activate phospholipase C (PLC) in rat frontal cortex. Using an exogenous substrate to measure PLC activity, we demonstrated that a tricyclic AD, imipramine, stimulated PLC activity of the frontal cortex membrane in a concentration-dependent manner. Two… CONTINUE READING
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