Imipramine metabolites in blood of patients during therapy and after overdose.

@article{Gram1983ImipramineMI,
  title={Imipramine metabolites in blood of patients during therapy and after overdose.},
  author={Lars Freng Gram and Marianne Bjerre and Per Kragh-S\orensen and Birgit Kvinesdal and Johan Molin and O. Lindegaard Pedersen and Niels Reisby},
  journal={Clinical pharmacology and therapeutics},
  year={1983},
  volume={33 3},
  pages={335-42}
}
Plasma or serum concentrations of imipramine and five of its nonconjugated metabolites (desipramine, 2-OH-imipramine, 2-OH-desipramine, imipramine-N-oxide, and didesipramine) were followed in three cases of imipramine overdose and during steady state in 24 patients on continuous imipramine treatment. In the overdose cases the imipramine and desipramine concentrations declined monoexponentially with t 1/2s of 12 to 21 and 31 to 37 hr. The 2-OH-imipramine and 2-OH-desipramine levels were lower… CONTINUE READING