Imipramine inhibition of transient K+ current: an external open channel blocker preventing fast inactivation.

@article{Kuo1998ImipramineIO,
  title={Imipramine inhibition of transient K+ current: an external open channel blocker preventing fast inactivation.},
  author={C C Kuo},
  journal={Biophysical journal},
  year={1998},
  volume={75 6},
  pages={2845-57}
}
  • C C Kuo
  • Published 1998 in Biophysical journal
Rapidly inactivating K+ current (KA current) is recorded from rat hippocampal neurons by whole-cell patch-clamp technique and suitable voltage protocols. It is found that imipramine, a commonly prescribed tricyclic antidepressant, is an open KA channel blocker with a binding rate constant of 5.6 x 10(6) M-1 s-1 and an apparent dissociation constant of no more than 6 microM if applied extracellularly in pH 7.4. The inhibitory effect is more pronounced in more alkaline extracellular solution… CONTINUE READING

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