Imipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats.

@article{Schiavon2010ImipramineEC,
  title={Imipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats.},
  author={Ang{\'e}lica Pupin Schiavon and Humberto Milani and C{\'a}ssia Val{\'e}rio Romanini and Maira Licia Foresti and Olagide Wagner de Castro and Norberto Garcia-Cairasco and R{\'u}bia W de Oliveira},
  journal={Neuroscience letters},
  year={2010},
  volume={470 1},
  pages={43-8}
}
This study was aimed to determine whether imipramine chronic treatment promotes neurogenesis in the dentate gyrus (DG) and interferes with neuronal death in the CA1 subfield of the hippocampus after transient global cerebral ischemia (TGCI) in rats. After TGCI, animals were treated with imipramine (20mg/kg, i.p.) or saline during 14 days. 5-Bromo-2'-deoxyuridine-5'-monophosphate (BrdU) was injected 24h after the last imipramine or saline injection to label proliferating cells. In order to… CONTINUE READING