Imipramine-associated hyperpigmentation.

  title={Imipramine-associated hyperpigmentation.},
  author={Charles Edward Dean and Frank M Grund},
  journal={The Annals of pharmacotherapy},
  volume={37 6},
OBJECTIVE To inform clinicians of the potential for severe and persistent facial hyperpigmentation with the long-term use of imipramine. CASE SUMMARY A 65-year-old white male veteran with a history of paranoid schizophrenia was referred to the psychiatry service by a dentist who thought that the patient was both cyanotic and psychotic. The history and biopsy results indicated the possibility of imipramine-associated hyperpigmentation, only the second reported case in a male patient. The… CONTINUE READING