Imipenem resistance in Klebsiella pneumoniae is associated to the combination of plasmid-mediated CMY-4 AmpC β-lactamase and loss of an outer membrane protein.

@article{Dahmen2012ImipenemRI,
  title={Imipenem resistance in Klebsiella pneumoniae is associated to the combination of plasmid-mediated CMY-4 AmpC β-lactamase and loss of an outer membrane protein.},
  author={Safia Dahmen and Wejd{\`e}ne Mansour and Karama Charfi and Noureddine Bouj{\^a}afar and Guillaume Arlet and Olfa Bouall{\`e}gue},
  journal={Microbial drug resistance},
  year={2012},
  volume={18 5},
  pages={479-83}
}
This study was conducted to identify the molecular mechanisms of imipenem resistance in a Klebsiella pneumoniae (Kp16137) isolate recovered in August 2008 at the University Hospital Sahloul, Sousse, Tunisia. The strain was identified with the API 20E system; antibiotic-containing disks were used for detection of antibiotic susceptibility by a disk diffusion assay. We investigated the presence of β-lactamases by PCR, using specific primers for bla(TEM), bla(SHV), bla(CTX-M), bla(OXA), bla(CMY… CONTINUE READING
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