Imipenem: first of a new class of beta-lactam antibiotics.

  title={Imipenem: first of a new class of beta-lactam antibiotics.},
  author={Michael Barza},
  journal={Annals of internal medicine},
  volume={103 4},
Imipenem, the first of a new class of carbapenem antibiotics, has potent activity against most clinically important species of bacteria, including isolates resistant to other antibiotics. The drug is well distributed to most tissues and fluids after intravenous administration; however, levels in cerebrospinal fluid are modest. Most of the drug is eliminated in the urine, where it is metabolized by an enzyme on the brush border of the renal tubular cells; cilastatin is given simultaneously to… CONTINUE READING


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