Imipenem: a potent inducer of multidrug resistance in Acinetobacter baumannii.

@article{Kuo2012ImipenemAP,
  title={Imipenem: a potent inducer of multidrug resistance in Acinetobacter baumannii.},
  author={Han-Yueh Kuo and Ku Young Chang and Jonathan Kuo and Hui-Wen Yueh and Ming-Li Liou},
  journal={International journal of antimicrobial agents},
  year={2012},
  volume={39 1},
  pages={
          33-8
        }
}
This study investigated the progression of multidrug resistance upon exposure to imipenem in Acinetobacter baumannii. Eighteen A. baumannii strains, including two reference strains (ATCC 19606 and ATCC 17978), four clinical strains (AB56, AB242, AB273 and AB279) and 12 antibiotic-selected mutant strains, were used in this study. Imipenem-selected mutants were generated from imipenem-susceptible strains (ATCC 19606, ATCC 17978 and AB242) by multistep selection resistance. Amikacin… CONTINUE READING
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