Iminosugar derivative WGN-26 suppresses acute allograft rejection via inhibiting the IFN-γ/p-STAT1/T-bet signaling pathway.

  title={Iminosugar derivative WGN-26 suppresses acute allograft rejection via inhibiting the IFN-$\gamma$/p-STAT1/T-bet signaling pathway.},
  author={X. Gao and H. Yang and Yang-guang Xu and Yulan Xiong and G. Wang and Xinshan Ye and J. Ye},
  journal={International immunopharmacology},
  volume={23 2},
This study aimed to investigate the effect of the iminosugar derivative WGN-26 on suppressing acute allograft rejection and to explore the underlying mechanisms. The results demonstrated that WGN-26 (12, 6 and 3mg/kg) significantly prolonged the skin allograft survival time in a dose-dependent manner and minimized the pathological changes. The minimum lethal dose was 320 mg/kg. By exploring the potential cellular and molecular mechanisms, we found that WGN-26 dose-dependently inhibited T… Expand
5 Citations


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