Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.


The development of renin inhibitors with favorable oral pharmacokinetic profiles has been a longstanding challenge for the pharmaceutical industry. As part of our work to identify inhibitors of BACE1, we have previously developed iminopyrimidinones as a novel pharmacophore for aspartyl protease inhibition. In this letter we describe how we modified… (More)
DOI: 10.1016/j.bmcl.2015.02.003


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