Iminoheterocycle as a druggable motif: BACE1 inhibitors and beyond.

  • Zhaoning Zhu
  • Published 2012 in Trends in pharmacological sciences

Abstract

Beta-secretase 1 (BACE1) is a central nervous system (CNS) aspartyl protease required for production of amyloid beta (Aβ) peptides. Brain-penetrant BACE1 inhibitors are central to test the 'amyloid hypothesis', which suggests that a reduction of Aβ species in the CNS would halt or even reverse Alzheimer's disease. Discovery of the iminoheterocycle class of… (More)
DOI: 10.1016/j.tips.2012.02.003

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