Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold.

@article{Yngve2012ImidazopyridinebasedIO,
  title={Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold.},
  author={Ulrika. Yngve and Peter Soederman and Mats Svensson and Susanne Rosqvist and Per I Arvidsson},
  journal={Chemistry & biodiversity},
  year={2012},
  volume={9 11},
  pages={
          2442-52
        }
}
In this study, we explored the effect of bioisostere replacement in a series of glycogen synthase kinase 3 (GSK3) inhibitors based on the imidazopyridine core. The synthesis and biological evaluation of a number of novel sulfonamide, 1,2,4-oxadiazole, and thiazole derivates as amide bioisosteres, as well as a computational rationalization of the obtained results are reported. 
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