Imidazoline receptors in rat liver cells: a novel receptor or a subtype of alpha 2-adrenoceptors?

@article{Zonnenchein1990ImidazolineRI,
  title={Imidazoline receptors in rat liver cells: a novel receptor or a subtype of alpha 2-adrenoceptors?},
  author={R Zonnenchein and Sophia Diamant and Daphne Atlas},
  journal={European journal of pharmacology},
  year={1990},
  volume={190 1-2},
  pages={203-15}
}
An imidazoline/guanidine receptor has been characterized in rat liver cells. Binding of [3H]idazoxan, a selective benzodioxan antagonist, to imidazoline receptor on intact fresh hepatocytes (Bmax = 801 +/- 23 fmol/mg protein, Kd = 11 +/- 0.8 nM) and to liver membranes (Bmax = 400 +/- 38 fmol/mg protein, Kd = 10 +/- 2 nM) was saturable at 4 degrees C within 3.5 h and at 30 degrees C within 30 min, respectively. Rat lung membranes had more imidazoline sites (Bmax = 578 +/- 30 fmol/mg protein, Kd… CONTINUE READING

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