Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery.

@article{Zaitsev1996ImidazolineCS,
  title={Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery.},
  author={Sergei V. Zaitsev and Alexandre M Efanov and Ioulia B Efanova and Olof Flodmark Elna - Marie Larsson and C G Ostenson and Ginger Gold and Per Olof Berggren and Suad Efend{\'i}c},
  journal={Diabetes},
  year={1996},
  volume={45 11},
  pages={1610-8}
}
A novel imidazoline compound, RX871024, was used to investigate the mechanisms by which imidazoline derivatives promote insulin secretion in rat pancreatic beta-cells and HIT T15 cells. RX871024 stimulated insulin release from rat pancreatic beta-cells and HIT T15 cells in a glucose-dependent way. This effect was not related to alpha2-adrenergic, I1-, and I2-imidazoline receptors. RX871024 promoted insulin release by at least two modes of action. One included an increase in cytoplasmic free Ca2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Similar Papers

Loading similar papers…