Imidazoline binding sites mediates anticompulsive-like effect of agmatine in marble-burying behavior in mice.

@article{Dixit2014ImidazolineBS,
  title={Imidazoline binding sites mediates anticompulsive-like effect of agmatine in marble-burying behavior in mice.},
  author={Madhura P. Dixit and Prajwal P. Thakre and Akshay S Pannase and Manish Manohar Aglawe and Brijesh Gulabrao Taksande and Nandkishor R Kotagale},
  journal={European journal of pharmacology},
  year={2014},
  volume={732},
  pages={
          26-31
        }
}
The involvement of GABAergic system in the antidepressant-like effect of agmatine
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Results suggest that the effect of agmatine in the TST may involve an activation of GABA A receptors dependent on NMDA receptor inhibition, similar to ketamine, as well as modulation of GABA B receptors.
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PT611. The combination of sub-effective doses of agmatine and ketamine reduces obsessive-compulsive-like behavior of mice in marble burying test
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Insights into the Mn2+ Binding Site in the Agmatinase-Like Protein (ALP): A Critical Enzyme for the Regulation of Agmatine Levels in Mammals
TLDR
The results indicate that the central-ALP contains the active site for agmatine hydrolysis, as well as that the residues identified are relevant for the ALP catalysis.
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References

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5-HT1A-receptor subtype mediates the effect of fluvoxamine, a selective serotonin reuptake inhibitor, on marble-burying behavior in mice.
TLDR
From these results, the 5-HT1A-receptor subtype may be involved in the suppressive effect of fluvoxamine on the marble-burying, but the5-HT2-re receptor subtype is not involved in this effect.
Agmatine produces antidepressant-like effects in two models of depression in mice
TLDR
Data demonstrate that agmatine elicited a significant antidepressant-like effect through a mechanism that seems to involve an interaction with NMDA receptors, the L-arginine-nitric oxide pathway and &agr;2-adrenoceptors.
Anxiolytic effect of agmatine in rats and mice.
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