Imidazoline binding sites mediates anticompulsive-like effect of agmatine in marble-burying behavior in mice.

@article{Dixit2014ImidazolineBS,
  title={Imidazoline binding sites mediates anticompulsive-like effect of agmatine in marble-burying behavior in mice.},
  author={Madhura P. Dixit and Prajwal P. Thakre and Akshay S Pannase and Manish Manohar Aglawe and Brijesh Gulabrao Taksande and Nandkishor R Kotagale},
  journal={European journal of pharmacology},
  year={2014},
  volume={732},
  pages={
          26-31
        }
}
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The treatment with both imidazoline receptor antagonists was associated with important sedative effects in the Actimeter test in rats, and the effects of idazoxan were more intense than those of efaroxan in this experimental behavioural model.
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PT611. The combination of sub-effective doses of agmatine and ketamine reduces obsessive-compulsive-like behavior of mice in marble burying test
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A schizophrenic patient who, after being switched from escitalopram to milnacipran, showed a rapid improvement of his debilitating OCD, and review of the literature indicates that adding aripiprazole to an SSRIs could be a valid strategy for treatment-resistant OCD patients or those with only a partial therapeutic response.
Metabolic strategies for the degradation of the neuromodulator agmatine in mammals.
Idazoxan and Efaroxan Potentiate the Endurance Performances and the Antioxidant Activity of Ephedrine in Rats
TLDR
Idazoxan and efaroxan potentiated the physical effort-related effects of ephedrine with regard to endurance capacity and antioxidant activity in rats.
Agmatine inhibits nicotine withdrawal induced cognitive deficits in inhibitory avoidance task in rats: Contribution of α2-adrenoceptors
Insights into the Mn2+ Binding Site in the Agmatinase-Like Protein (ALP): A Critical Enzyme for the Regulation of Agmatine Levels in Mammals
TLDR
The results indicate that the central-ALP contains the active site for agmatine hydrolysis, as well as that the residues identified are relevant for the ALP catalysis.
Agmatine attenuates hyperactivity and weight loss associated with activity-based anorexia in female rats
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References

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Antidepressant-like effect of agmatine and its possible mechanism.
Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats.
5-HT1A-receptor subtype mediates the effect of fluvoxamine, a selective serotonin reuptake inhibitor, on marble-burying behavior in mice.
TLDR
From these results, the 5-HT1A-receptor subtype may be involved in the suppressive effect of fluvoxamine on the marble-burying, but the5-HT2-re receptor subtype is not involved in this effect.
Psychopharmacological study of agmatine in behavioral tests of schizophrenia in rodents
Agmatine produces antidepressant-like effects in two models of depression in mice
TLDR
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Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine
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