Imidazolidin-2-one prostaglandin analogues.

  title={Imidazolidin-2-one prostaglandin analogues.},
  author={P. P. Barraclough and William Peter Uprichard Jackson and Cynthia J. Harris},
  journal={Archiv der Pharmazie},
  volume={324 8},
The 5-desoxy analogue of BW245C, imidazolidin-2-one 3, has been synthesized by reduction of the N-benzyl hydantoin derivative 6. Compound 3 was found to be approximately equipotent with BW245C as an inhibitor of platelet aggregation and this result indicates that the 5-keto group of BW245C is not essential for platelet inhibitory activity.