Imidazole-buffered cardioplegic solution. Improved myocardial preservation during global ischemia.

Abstract

Progressive acidosis is a constant finding in global myocardial ischemia and is associated with reduced myocardial contractility after ischemia. The hypothesis tested in these experiments was that imidazole (pKa = 6.7 at 37 degrees C), a commonly used buffer in physiology and microbiology, would provide superior buffering capacity when used in lieu of… (More)

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@article{Woude1985ImidazolebufferedCS, title={Imidazole-buffered cardioplegic solution. Improved myocardial preservation during global ischemia.}, author={Judith Vander Woude and Ignacio Y. Christlieb and Gregorio A. Sicard and Richard E. Clark}, journal={The Journal of thoracic and cardiovascular surgery}, year={1985}, volume={90 2}, pages={225-34} }