Imidazole antimycotics: inhibitors of steroid aromatase.

  title={Imidazole antimycotics: inhibitors of steroid aromatase.},
  author={James Ian Mason and Barbara A Murry and Michael C. Olcott and Joel J. Sheets},
  journal={Biochemical pharmacology},
  volume={34 7},
Miconazole and clotrimazole, members of a class of imidazole agents which have broad spectrum antimycotic activity, were shown to be potent inhibitors of steroid aromatase activity of human placental microsomes. The I50 values for the inhibition of aromatase activity by miconazole, clotrimazole, ketoconazole, and aminoglutethimide were 0.6, 1.8, 60 and 44 microM respectively. The most effective compound, miconazole, exhibited competitive kinetics with respect to androstenedione, the aromatase… CONTINUE READING

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