Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.

@article{Giusti1993ImidazenilAN,
  title={Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.},
  author={Pietro Giusti and Ivan Ducic and Giulia Puia and Roberto Arban and Armin Walser and Alessandro Guidotti and Erminio Costa},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={266 2},
  pages={1018-28}
}
Positive allosteric modulators of gamma-aminobutyric acid (GABA)A receptors, including benzodiazepines and congeners, can be classified into three categories: 1) full allosteric modulators (i.e., triazolam and alprazolam) that act with high potency and efficacy at many GABAA receptors; 2) selective allosteric modulators (i.e., diazepam) that act with high potency and high efficacy at selected GABAA receptors; and 3) partial allosteric modulators (i.e., bretazenil) that act with high potency but… CONTINUE READING

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