Imidazenil: An antagonist of the sedative but not the anticonvulsant action of diazepam

@article{Auta2005ImidazenilAA,
  title={Imidazenil: An antagonist of the sedative but not the anticonvulsant action of diazepam},
  author={J. Auta and E. Costa and J. Davis and A. Guidotti},
  journal={Neuropharmacology},
  year={2005},
  volume={49},
  pages={425-429}
}
Flumazenil (FLU), a specific benzodiazepine (BZ) receptor antagonist has been used in the treatment of acute BZ intoxication or the alleviation of BZ-induced withdrawal syndrome on the basis of its weak partial agonist action at GABA(A) receptors. However, given to patients, FLU can worsen diazepam-induced withdrawal syndrome by lowering seizure threshold. We therefore investigated whether imidazenil, a selective positive allosteric modulator of GABA action at GABA(A) receptors containing… Expand
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