Imbalanced globin chain synthesis in heterozygous beta-thalassemic bone marrow.

  title={Imbalanced globin chain synthesis in heterozygous beta-thalassemic bone marrow.},
  author={George Chalevelakis and John B. Clegg and David J. Weatherall},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={72 10},
Globin synthesis was studied in the bone marrow of seven heterozygous beta-thalassemic subjects. We found evidence of significant imbalance of alpha- and beta-chain production particularly at short times of incubation. There was a progressive decrease in alpha/beta-chain production ratio with increasing incubation time which was due to a decreased rate of net alpha-chain production, indicating that a large proportion of the newly synthesized alpha chains are degraded, particularly in bone… CONTINUE READING

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