Imbalanced globin chain synthesis in cultured erythroid progenitor cells from thalassemic bone marrow and peripheral blood.

@article{Ritchey1981ImbalancedGC,
  title={Imbalanced globin chain synthesis in cultured erythroid progenitor cells from thalassemic bone marrow and peripheral blood.},
  author={Arthur Kim Ritchey and Ronald M Hoffman and E Coupal and V D Floyd and Howard A. Pearson and Bernard G. Forget},
  journal={Blood},
  year={1981},
  volume={57 4},
  pages={788-93}
}
The plasma clot culture system was utilized to support the growth of erythroid-committed stem cells from the bone marrow of five patients with homozygous -thalassemia and the peripheral blood of one patient doubly heterozygous for j9#{176}-thalassemia and Hb Lepore. Addition of erythropoietin to the cultures resulted in abundant colony growth (76-185 CFU-E… CONTINUE READING