Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation

@inproceedings{Zhang2018ImbalancedLA,
  title={Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation},
  author={Yue Xia Zhang and Jiaolong Shi and Yuxin Fang and Chuncai Gu and Jianqun Cai and Chuang Lin and Aimin Li and Liang Zhao and Side Liu},
  booktitle={Cell Death & Disease},
  year={2018}
}
Epithelial–mesenchymal transition (EMT)-induced metastasis contributes to human colorectal cancer (CRC) progression, especially in advanced CRC. However, the underlying mechanism of β-catenin in this process is elusive. We identified that LIM domain kinase (LIMK)2 was progressively downregulated with tumor progression from precancerous lesions to advanced cancer. Gain- and loss-of-function assays revealed that LIMK2 inhibits cell proliferation via cell cycle arrest at the G1–S transition and… CONTINUE READING
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