Imbalance of total cellular nucleotide pools and mechanism of the colchicine-induced cell activation.

  title={Imbalance of total cellular nucleotide pools and mechanism of the colchicine-induced cell activation.},
  author={I. N. Chou and Joel Zeiger and Eliezer Rapaport},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={81 8},
  • I. ChouJ. ZeigerE. Rapaport
  • Published 1 April 1984
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
Treatment with colchicine or vinblastine, both inhibitors of microtubule assembly, renders quiescent 3T3 cells in an "activated state" as evidenced by induction of DNA synthesis and other criteria. Microtubule disassembly caused by colchicine or vinblastine brings about a dramatic expansion of total cellular UTP pools with a concomitant diminution in total cellular ATP pools, thus resulting in a marked imbalance in total cellular nucleotide pools. Colchicine and vinblastine also stimulate total… 

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