Imbalance of growth factor signalling in diabetic kidney disease: is connective tissue growth factor (CTGF, CCN2) the perfect intervention point?

@article{Nieuwenhoven2005ImbalanceOG,
  title={Imbalance of growth factor signalling in diabetic kidney disease: is connective tissue growth factor (CTGF, CCN2) the perfect intervention point?},
  author={Frans A. van Nieuwenhoven and Louise Jung N{\o}rgaard Jensen and Allan Flyvbjerg and Roel Goldschmeding},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2005},
  volume={20 1},
  pages={
          6-10
        }
}
The prevalence of diabetes mellitus and its clinical complications are increasing rapidly worldwide. Diabetic nephropathy has already become the leading cause of end-stage renal disease in developed countries and is thus forming an increasing clinical problem [1]. Mesangial matrix accumulation and glomerular basement membrane (GBM) thickening are primary structural alterations characteristic for diabetic nephropathy [2]. These structural changes are accompanied by increased permeability of the… CONTINUE READING

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