Imbalance of T-cell subsets in angiotensin II-infused hypertensive rats with kidney injury.

@article{Shao2003ImbalanceOT,
  title={Imbalance of T-cell subsets in angiotensin II-infused hypertensive rats with kidney injury.},
  author={Jing Shao and Masaomi Nangaku and Toshio Miyata and Reiko Inagi and Koei Yamada and Kiyoshi Kurokawa and Toshiro Fujita},
  journal={Hypertension},
  year={2003},
  volume={42 1},
  pages={31-8}
}
Blockade of angiotensin (Ang) II is efficient in various renal diseases. Although interest has focused on the hemodynamic changes and reduction of proteinuria, recent studies emphasize the nonhemodynamic effects of Ang II on kidney injury. The aim of this study was to clarify the mechanisms of Ang II on the immune system that alter the balance of helper T-cell (Th) subsets. We used a continuous, Ang II infusion model of rats that develop hypertension, proteinuria, and tubulointerstitial damage… CONTINUE READING