Imbalance in treatment assignments in stratified blocked randomization.

@article{Hallstrom1988ImbalanceIT,
  title={Imbalance in treatment assignments in stratified blocked randomization.},
  author={Alfred P. Hallstrom and Kenneth S. Davis},
  journal={Controlled clinical trials},
  year={1988},
  volume={9 4},
  pages={375-82}
}
Blocking and stratification are used in preparing randomization assignments to ensure that there will be nearly equal numbers of patients in each treatment group and that the groups will be similar with respect to important covariates. Stratified blocked randomization will create near balance within strata, but imbalance for the total trial may still occur. The variance for the total trial imbalance D is derived and examples from clinical trials are given. Under reasonable assumptions, if the… CONTINUE READING

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