Imbalance in T-cell subsets of five children with congenital agammaglobulinemia and its effect on "in vitro" immunoglobulin synthesis.


OKT3, OKT4 and OKT8 monoclonal antibodies have been used to assess the number of total T cells and of some T-cell subpopulations in five children with Congenital Agammaglobulinemia. A significant increase in OKT8+ cells and parallel decrease in OKT4+ cells were observed in all patients, both as percentages and absolute numbers. by contrast there was no… (More)