Imbalance between tissue inhibitor of metalloproteinase-4 and matrix metalloproteinases during acute myocardial [correction of myoctardial] ischemia-reperfusion injury.

@article{Schulze2003ImbalanceBT,
  title={Imbalance between tissue inhibitor of metalloproteinase-4 and matrix metalloproteinases during acute myocardial [correction of myoctardial] ischemia-reperfusion injury.},
  author={Costas J. Schulze and Wenjie Wang and Wilma L. Suarez-Pinzon and Jolanta Sawicka and Grzegorz Sawicki and Richard Schulz},
  journal={Circulation},
  year={2003},
  volume={107 19},
  pages={2487-92}
}
BACKGROUND We have previously reported that matrix metalloproteinase-2 (MMP-2) contributes to myocardial ischemia-reperfusion injury by degradation of troponin I, a regulatory element of the contractile proteins. MMP activities are also tightly regulated by tissue inhibitors of metalloproteinase (TIMPs). The change in TIMPs during acute myocardial ischemia-reperfusion injury is not clear. METHODS AND RESULTS Isolated rat hearts were perfused either aerobically for 75 minutes or subjected to… CONTINUE READING

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