Imbalance between proliferation and apoptosis in the development of colorectal carcinoma

@article{Hao1998ImbalanceBP,
  title={Imbalance between proliferation and apoptosis in the development of colorectal carcinoma},
  author={Xingpei Hao and Mingqing Du and Anne E. Bishop and Ian C. Talbot},
  journal={Virchows Archiv},
  year={1998},
  volume={433},
  pages={523-527}
}
 To evaluate the relationship between cell proliferation and apoptosis in sporadic colorectal carcinogenesis, immunohistochemistry for proliferation-associated antigen Ki-67 and in situ end labelling for identifying apoptotic bodies were performed on paraffin sections from 59 adenomas and 22 carcinomas. These results were correlated with the expression of the proliferation and apoptosis modulators Bcl-2 and p53. Carcinomas showed increased proliferation and apoptosis compared with adenomas (P<0… CONTINUE READING

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Down - regulation Bcl - 2 by p 53 in breast cancer cells

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