Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: involvement of membrane-associated cytokines.

@article{Burger1998ImbalanceBI,
  title={Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: involvement of membrane-associated cytokines.},
  author={Danielle Burger and Roger Rezzonico and J M Li and C Modoux and Richard A. Pierce and Howard G. Welgus and Jean-Michel Dayer},
  journal={Arthritis and rheumatism},
  year={1998},
  volume={41 10},
  pages={1748-59}
}
OBJECTIVE To determine whether direct cell-cell contact with stimulated T lymphocytes (a) differentially modulates the production of interstitial collagenase (matrix metalloproteinase 1 [MMP-1]) and tissue inhibitor of metalloproteinases 1 (TIMP-1) on human synoviocytes and dermal fibroblasts, and (b) induces the production of prostaglandin E2 (PGE2); and to identify the membrane-associated factors on T cell surfaces involved in these mechanisms. METHODS Dermal fibroblasts and fibroblast-like… CONTINUE READING
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