Imbalance between cathepsin-B and cysteine proteinase-inhibitors is of prognostic-significance in human lung-cancer.

@article{Knoch1994ImbalanceBC,
  title={Imbalance between cathepsin-B and cysteine proteinase-inhibitors is of prognostic-significance in human lung-cancer.},
  author={H. Roebling Knoch and Bernd Werle and William L. Ebert and Eberhard Spiess},
  journal={International journal of oncology},
  year={1994},
  volume={5 1},
  pages={
          77-85
        }
}
In the study of 69 matched pairs of lung tumors and normal lung parenchyma, the median activities of cathepsin B (CB) and cystein proteinase inhibitors (CPI's) in tumors were found to be increased 4.4-fold and twofold, respectively. The levels of CB and CPI activities did not correlate with TNM stages nor with cell differentiation. In addition, CB activity did not vary across the histologies of lung cancer, while CPI activity was significantly higher in squamous cell carcinoma compared to the… CONTINUE READING
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