Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

  title={Imatinib radiosensitizes bladder cancer by targeting homologous recombination.},
  author={Boling Qiao and Martin Kerr and Blaz Groselj and Mark T W Teo and Margaret A Knowles and Robert G. Bristow and Roger M. Phillips and Anne E Kiltie},
  journal={Cancer research},
  volume={73 5},
Radiotherapy is a major treatment modality used to treat muscle-invasive bladder cancer, with patient outcomes similar to surgery. However, radioresistance is a significant factor in treatment failure. Cell-free extracts of muscle-invasive bladder tumors are defective in nonhomologous end-joining (NHEJ), and this phenotype may be used clinically by combining radiotherapy with a radiosensitizing drug that targets homologous recombination, thereby sparing normal tissues with intact NHEJ. The… CONTINUE READING
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