Imatinib promotes apoptosis of giant cell tumor cells by targeting microRNA-30a-mediated runt-related transcription factor 2.

@article{Liao2016ImatinibPA,
  title={Imatinib promotes apoptosis of giant cell tumor cells by targeting microRNA-30a-mediated runt-related transcription factor 2.},
  author={Yuxiang Liao and Guohua Lv and Bing Jie Wang and Lei Kuang and Xiaobin Wang},
  journal={Molecular medicine reports},
  year={2016},
  volume={13 2},
  pages={
          1739-45
        }
}
Giant cell tumor (GCT) is an aggressive type of bone tumor consisting of multinucleated osteoclast-like giant cells. Imatinib is a selective inhibitor for certain type III tyrosine kinase receptor family members with a variety of beneficial effects. The purpose of the present study was to determine the therapeutic potential and underlying mechanism of imatinib against GCT. In the present study, cell viability and apoptosis in GCT were analyzed using the MTT assay, flow cytometry and DAPI… CONTINUE READING
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