Imatinib mesylate and metabolite concentrations in maternal blood, umbilical cord blood, placenta and breast milk

@article{Russell2007ImatinibMA,
  title={Imatinib mesylate and metabolite concentrations in maternal blood, umbilical cord blood, placenta and breast milk},
  author={Mark A. Russell and Marshall W J Carpenter and Muhammad Saleem Akhtar and Theodore F. Lagattuta and Merrill J. Egorin},
  journal={Journal of Perinatology},
  year={2007},
  volume={27},
  pages={241-243}
}
Treatment of maternal chronic myeloid leukemia with imatinib mesylate is avoided because of potential fetal effects. Two women with progression of disease during pregnancy required imatinib therapy. Concentrations of imatinib in maternal blood, placenta, umbilical cord blood and breast milk were 886, 2452, 0 to 157, and 596 ng/ml, respectively. Concentrations of the active metabolite CGP74588 in maternal blood, placenta, umbilical cord blood and breast milk were 338, 1462, 0 and 1513 ng/ml… CONTINUE READING

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